10-Q quarterly report · filed Nov 3, 2025

CASTLE BIOSCIENCES INC (CSTL) Q3 2025 10-Q Quarterly Report

Short answer

CASTLE BIOSCIENCES INC (CSTL) filed its Q3 2025 10-Q quarterly report on Nov 3, 2025 for the quarter ended Sep 30, 2025. Quarterly revenue was $83M (down 3.2% year over year) with net income of −$501,000.

Q3 2025 key financials · XBRL

Revenue
$83M
−3.2% YoY · −3.6% QoQ
Net income
−$501,000
−122.1% YoY · −111.1% QoQ
Operating margin
-8.2%
EPS (diluted)
−$0.02
−125.0% YoY · −112.5% QoQ

Source: XBRL data from the CASTLE BIOSCIENCES INC (CSTL) Q3 2025 10-Q on SEC EDGAR. USD.

CASTLE BIOSCIENCES INC Q3 2025 10-Q analysis

AI summary of MD&A and risk factor updates

Management Discussion & Analysis

  • Test reports 26,841, up 3.2% YoY
  • TissueCypher strongest growth, 10,609 reports, up 74.7% YoY
  • IDgenetix weakest trend, 0 reports after discontinuation in May 2025
  • Near-term headwinds: Medicare noncoverage of DecisionDx-SCC and macroeconomic uncertainty

Risk Factors

  • Newly triggered coverage risk: Novitas LCD effective April 24, 2025 classifies DecisionDx-SCC as noncovered
  • Regulatory risk: FDA rescinded LDT final rule September 19, 2025 after Texas court vacatur, leaving future oversight uncertain
  • Reimbursement risk: DecisionDx-SCC revenue expected to decline materially from its significant 2024 contribution
  • Financial risk: Nine-month 2025 net loss $21.8 million and accumulated deficit $222.0 million
  • Operational risk: TissueCypher previously required a temporary order pause to address a significant testing backlog

Generated from the filing text; verify against the original. 10-K vs 10-Q vs 8-K

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