10-Q quarterly report · filed Jul 30, 2026

Alnylam Pharmaceuticals (ALNY) Q2 2026 10-Q Quarterly Report

Short answer

Alnylam Pharmaceuticals (ALNY) filed its Q2 2026 10-Q quarterly report on Jul 30, 2026 for the quarter ended Jun 30, 2026. Quarterly revenue was $2.5B (up 217.7% year over year) with net income of $370M.

Q2 2026 key financials · XBRL

Revenue
$2.5B
+217.7% YoY
Net income
$370M
+659.0% YoY
Operating margin
20.3%
EPS (diluted)
$2.71
+631.4% YoY

Source: XBRL data from the Alnylam Pharmaceuticals (ALNY) Q2 2026 10-Q on SEC EDGAR. USD.

Alnylam Pharmaceuticals Q2 2026 10-Q analysis

AI summary of MD&A and risk factor updates

Management Discussion & Analysis

  • AMVUTTRA revenue $1.01B; ONPATTRO $18.5M; GIVLAARI $89.8M; OXLUMO $52.1M in Q2 2026
  • Best product AMVUTTRA at $1.01B; lowest product ONPATTRO at $18.5M
  • 2028 Notes issuance $661.3M; capped-call payment $35.3M; 2027 Note repurchases totaled approximately $1.16B
  • Management targets 25%+ revenue CAGR and approximately 30% non-GAAP operating margin through 2030; continued significant R&D investment expected

Risk Factors

  • New AMVUTTRA concentration risk triggered by FDA approval for ATTR-CM in March 2025; sales comprised significant product revenue in 2025 and six months ended June 30, 2026
  • Most material commercial update: AMVUTTRA net product revenues reached $1.17 billion in Q2 2026 and $2.21 billion year-to-date
  • Regulatory risk from evolving drug-pricing rules, including potential U.S. government price negotiation and most-favored-nation measures
  • Competitive risk from additional ATTR-CM therapies or generic competing products reducing AMVUTTRA adoption and reimbursement
  • Financial risk from $3.31 billion in cash, equivalents and marketable securities exposed to credit, liquidity, market and interest-rate losses

Generated from the filing text; verify against the original. 10-K vs 10-Q vs 8-K

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