Tango Therapeutics, Inc. (TNGX) FY2025 10-K Annual Report

Filed: Mar 5, 2026
Health Care
Pharmaceutical PreparationsSEC EDGAR

Tango Therapeutics, Inc. (TNGX) 10-K annual report for fiscal year 2025, filed with SEC EDGAR on Mar 5, 2026. This page provides AI-powered analysis including business overview, management discussion & analysis (MD&A), risk factors, and key financial data such as revenue, net income, gross margin, operating margin, and return on equity (ROE) extracted from XBRL.

Tango Therapeutics, Inc. FY2025 10-K Analysis

Risk Factors

  • Regulatory risk: FDA clinical trial approvals and safety profiling of PRMT5 inhibitors vopimetostat and TNG456 ongoing with multiple Phase 1/2 trials active in 2026
  • Macroeconomic exposure: Cash runway of $343.1M as of Dec 31, 2025 expected to fund operations only into 2028, requiring substantial additional capital raises
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Tango Therapeutics, Inc. FY2025 Key Financial Metrics
XBRL

Revenue

$62M

+48.3% YoY

Net Income

-$102M

+22.0% YoY

Operating Margin

-178.4%

+16769bp YoY

Net Margin

-162.9%

+14688bp YoY

ROE

-29.3%

+3596bp YoY

Total Assets

$399M

+26.0% YoY

EPS (Diluted)

$-0.87

+26.9% YoY

Operating Cash Flow

-$139M

-5.6% YoY

Source: XBRL data from Tango Therapeutics, Inc. FY2025 10-K filing on SEC EDGAR. All figures in USD.

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