Alnylam Pharmaceuticals (ALNY) FY2025 10-K Annual Report
Alnylam Pharmaceuticals (ALNY) 10-K annual report for fiscal year 2025, filed with SEC EDGAR on Feb 12, 2026. This page provides AI-powered analysis including business overview, management discussion & analysis (MD&A), risk factors, and key financial data such as revenue, net income, gross margin, operating margin, and return on equity (ROE) extracted from XBRL.
Alnylam Pharmaceuticals FY2025 10-K Analysis
Business Overview
- • Achieved first profitability in 2025 with net product revenues approx. $3.0B, primarily from TTR franchise growth
- • Initiated Phase 3 trials in 2025 for nucresiran (next-gen TTR silencer) and zilebesiran (hypertension), emphasizing late-stage pipeline expansion
Risk Factors
- • Regulatory risk from U.S. drug price control measures, Medicare/Medicaid reimbursement changes potentially reducing AMVUTTRA net price
- • Geopolitical exposure to foreign currency fluctuations in Japanese yen, Euro, and British pound affecting revenues and expenses
Alnylam Pharmaceuticals FY2025 Key Financial MetricsXBRL
Revenue
$3.7B
▲ +65.2% YoY
Net Income
$314M
▲ +212.8% YoY
Operating Margin
13.5%
▲ +2137bp YoY
Net Margin
8.4%
▲ +2082bp YoY
ROE
39.8%
▲ +45437bp YoY
Total Assets
$5.0B
▲ +17.1% YoY
EPS (Diluted)
$2.33
▲ +206.9% YoY
Operating Cash Flow
$524M
▲ +6405.1% YoY
Source: XBRL data from Alnylam Pharmaceuticals FY2025 10-K filing on SEC EDGAR. All figures in USD.
Get deeper insights on Alnylam Pharmaceuticals
Access full AI analysis, insider trading data, fund holdings, and cross-signal detection on SignalX.