MDGL MADRIGAL PHARMACEUTICALS, INC.

FY2025 10-K
Filed: Feb 19, 2026
Health Care
Pharmaceutical PreparationsSEC EDGAR

MADRIGAL PHARMACEUTICALS, INC. (MDGL) filed its fiscal year 2025 10-K annual report with the SEC on Feb 19, 2026. This page provides AI-powered analysis of the filing, including business overview, management discussion, risk factors, and key financial metrics from XBRL data.

AI Filing Analysis
FY2025 10-K

Business Overview

  • Core business model: development and commercialization of pharmaceutical therapies for liver diseases, primarily noncirrhotic MASH
  • New product: Launch and full-year commercialization of Rezdiffra in U.S. (approved Mar 2024) and market entry in Germany (Sep 2025)
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Management Discussion & Analysis

  • No revenue or YoY change figures provided in the MD&A
  • No profitability or margin percentages disclosed
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Risk Factors

  • Regulatory risk: accelerated approval of Rezdiffra under FDA Subpart H pathway contingent on completing MAESTRO-NASH trials for full approval
  • Geopolitical/macro risk: U.S. Medicare drug price negotiation program starting 2026 may cap prices and impose rebates on high-spend drugs like Rezdiffra
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Financial Summary
XBRL

Revenue

$958M

Net Income

-$288M

Operating Margin

-31.3%

Net Margin

-30.1%

ROE

-47.8%

Total Assets

$1.3B

EPS (Diluted)

$-12.85

Operating Cash Flow

-$190M

Source: XBRL data from MADRIGAL PHARMACEUTICALS, INC. FY2025 10-K filing on SEC EDGAR. All figures in USD.

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