Guardant Health, Inc. (GH) FY2025 10-K Annual Report
Guardant Health, Inc. (GH) 10-K annual report for fiscal year 2025, filed with SEC EDGAR on Feb 19, 2026. This page provides AI-powered analysis including business overview, management discussion & analysis (MD&A), risk factors, and key financial data such as revenue, net income, gross margin, operating margin, and return on equity (ROE) extracted from XBRL.
Guardant Health, Inc. FY2025 10-K Analysis
Business Overview
- • Core business: Precision oncology company providing liquid biopsy and blood-based tests for cancer detection, treatment selection, and monitoring across all disease stages
- • New emphasis: Expanded Guardant Reveal test for late-stage therapy response monitoring; Shield test granted FDA Breakthrough Device status for multi-cancer detection
Management Discussion & Analysis
- • Revenue $982.0M in 2025 vs $739.0M in 2024, up $243M or 32.9% YoY
- • Net loss improved to $416.3M in 2025 from $436.4M in 2024, margin not explicitly stated
Risk Factors
- • Medicare reimbursement 10%+ of revenue in 2025, 2024, 2023; risk from CMS regulation changes hindering direct billing
- • Geopolitical and economic instability, including wars, terrorism, pandemics, may disrupt business and affect operating results
Guardant Health, Inc. FY2025 Key Financial MetricsXBRL
Revenue
$982M
▲ +32.9% YoY
Net Income
-$416M
▲ +4.6% YoY
Operating Margin
-44.5%
▲ +1550bp YoY
Net Margin
-42.4%
▲ +1666bp YoY
ROE
419.2%
▲ +10670bp YoY
Total Assets
$2.0B
▲ +35.5% YoY
EPS (Diluted)
$-3.32
▲ +6.7% YoY
Operating Cash Flow
-$185M
▲ +23.0% YoY
Source: XBRL data from Guardant Health, Inc. FY2025 10-K filing on SEC EDGAR. All figures in USD.
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